Ain Chung, Ph.D.
May 26(Thu) - May 26(Thu), 2022
12PM
Online zoom (ID: 728-142-6028)
Neuro@noon Seminar
Date: 12:00 PM, Thursday, May 26th
Speaker: Ain Chung, Ph.D.
(Massachusetts General Hospital, Harvard medical school)
Title: Neurobiology of learning to learn: Neural mechanisms underlying sustained cognitive enhancement
Abstract: Learning and memory are fundamental cognitive processes that allow animals to persistently and stably store information and flexibly adapt to dynamic environments. My research has focused on how persistent changes to circuit functions allow our brain to acquire long-lasting memory while accomplishing sustained cognitive enhancement in new learning. First, I investigated the cellular encoding mechanisms of aversive memories in the amygdala in rats. I found that associations that benefit an animal’s survival activate amygdala neurons convergently and generate persistent memory. Next, I investigated how cognitive control training induces general cognitive enhancement by altering hippocampal neural circuit function beyond forming specific and explicit memories. I showed that cognitive control facilitated learning new tasks and rapidly changed medial entorhinal cortex (MEC)-to-dentate gyrus (DG) synaptic circuit function, resulting in an excitatory-inhibitory sub-circuit change that persists for months. Specifically, cognitive control training increases inhibition that attenuates the DG response to MEC input and, through disinhibition, potentiates the response to strong inputs, pointing to overall signal-to-noise enhancement. Lastly, I studied whether genetically increasing neurogenesis recruits inhibitory interneuron plasticity in the hippocampus to improve social memory. I found that enhancing neurogenesis promoted social recognition, augmented PV inhibitory contacts in CA2 and enhanced functional inhibitory synaptic inputs onto CA2. These neurobiological findings suggest that sustained circuit function changes store item–event associations and optimize information processing for improving cognition.