Multifunctional Optoelectronics and Flexible Electronics
1. Printed Electronics (Printed single crystal silicon MOSFET& micro LED)
2. Bio-Integrated devices for Bio-medical Applications, Optogenetics
3. Wearable, skin electronics
Nano-materials and Nanoprocesses
1. Bio-inspired nanoscale sensors (or gecko lizard like Stooped nanohairs, Superhydrophobic (omniphobic) surface)
2. Development of Nanopatterning fabrcated by soft lithography, nano-imprint lithography
3. Wettability Control on Nano Strucutres (unidirectional wetting, micro fluidic channel)
1. D. Kang, P.V. Pikhitsa, Y.W. Choi, C. Lee, S.S. Shin, L. Piao, B. Park, K.-Y. Suh, Tae-il Kim*, M. Choi, "Ultransensitive mechanical crack-based sensor inspired by the spider sensory system", Nature 516: 222-226, 2014.
2. Tae-il Kim†, J.G. McCall†, Y.H. Jung, X, Huang, E. R. Siuda, Y. Li, J. Song, Y.M. Song, H.A. Pao, R. -H. Kim, Lu, S. D. Lee, I.-S. Song, G.C. Shin, R. Al-Hassani, S. Kim, M.P. Tan, Y. Huang, F.G. Omenetto, John.A. Rogers, M.R. Bruchas, "Injectable cellular scale optoelectronics with applications for wireless optogenetics", Science 340: 211-216, 2013.
3. Jordan McCall†, Tae-il Kim†, Gunchul Shin†, Xian Huang, Yei Hwan Jung, Fiorenzo G. Omenetto, Micheal R Bruchas, John A. Rogers, "Fabrication of flexible, multimodal light emitting devices for wireless optogenetics", Nat. Protoc. 8 2413-242, 2013.
4. Tae-il Kim†, C. Pang†, W. K. Bea, D.-S. Kang, S. M. Kim and K. Y. Suh, "Bioinspired Reversible Interlocker Using Regularly Arrayed High Aspect-Ratio Polymer Fibers", Adv. Mater. 24(4): 475-479, 2012. [selected as a front cover]
5. Tae-il Kim†, H.-J. Chung†, H.-S.Kim, S. A. Wells, S. Jo, N. Ahmed, Y. H. Jung, S. M. Won, C. A. Bower, John. A. Rogers, “Fabrication of releasable single crystal silicon metal oxide field effect devices and their assembly on foreign substrates”, Adv. Func. Mater. 21(16): 3029-3036, 2011. [selected as a front cover]
Lab Name: Cancer biology lab
Introduction
The DNA damage response (DDR) is essential for preserving genomic integrity in eukaryotes. At the start of the DDR network are the ATM and ATR kinases, which impose their regulation on multiple repair pathways via damage-induced phosphorylation. The overall goal of our laboratory is to understand the molecular mechanisms underlying genomic instability and tumorigenesis using DNA damage signaling pathway. The maintenance of genomic integrity following DNA damage depends on the interaction of DNA repair with cell cycle checkpoint controls. The integrity of the DNA damage response pathway is crucial for the prevention of neoplastic transformation, as suggested by the fact that many proteins involved in these pathways are tumor suppressors including p53, ATM, Chk2, RAP80, BRCA1 and BRCA2. Our group has discovered and studied many new components involved in DNA damage pathways. Recently, our group also studied other areas of genomic instability, including mitotic regulation. Our lab is also studying a signal transduction pathway in brain.
Selected Recent Publications
1. Lee NS, Chung HJ, Kim HJ, Lee SY, JJi J, Seo Y, Han SH, Choi M, Yun M, Lee SG, Myung K, Kim Y, Kang HC, Kim H, Nature communication, 2015.
2. Cho HJ, Oh YJ, Han SH, Chung HJ, Kim CH, Lee NS, Kim WJ, Choi JM, Kim H,"Cdk1 protein-mediated phosphorylation of receptor-associated protein 80 (RAP80) serine 677 modulates DNA damage-induced G2/M checkpoint and cell survival" J Biol Chem 8;288(6): 3768-76, 2013.
3. Kim H, Lee JE, Shin ES, Yoo YK, Cho JH, Yun MH, Kim YH, Kim SK, Kim HJ, Jang TW, Kwak SM, Kim CS, Ryu JS, "Effect of BRCA1 haplotype on survival of non-small-cell lung cancer patients treated with platinum-based chemotherapy", J Clin Oncol 26(36): 5972-5979, 2008.
4. Hongtae Kim, Jun Huang & Junjie Chen, "CCDC98 is a BRCA1-BRCT domain–binding protein involved in the DNA damage response", Nature structure& Molecular biology, 14: 710-715, 2007.
5. Hongtae Kim, Junjie Chen* and Xiaochun Yu* (*To whom correspondence should be addressed), "Ubiquitin-binding protein mediates BRCA1-dependent DNA damage responses", Science 316 : 1202-1205, 2007.
Since November, 2020
Office No. B437
Since August, 2021
Office No. B417
Since October, 2022
Office No. 428
Since October, 2022
Office No. 428
Since March, 2023
Office No. B413
Since September, 2023
Office No. 411
Since September, 2023
Office No. 437
Since September, 2024
Office No. 430
Major Experience
1991-1996 Senior Research Scientist, Research Center of Chong Kun Dang Pharmaceutical Company, Seoul, Korea
2001-2003 Postdoctoral Fellow, Department of Pathology Harvard Medical School
2004-2008 Assistant Professor, School of Life Sciences, Gwangju Institute of Science and Technology (GIST)
2008-2012 Associate Professor, School of Life Sciences, Gwangju Institute of Science and Technology (GIST)
2012-2013 Professor, School of Life Sciences, Gwangju Institute of Science and Technology (GIST)
2014~present Professor, Division of Integrative Biosciences and Biotechnology, POSTECH
Research Interests
Role of transcription factors (Ets1 and NFAT1) in immune regulation and tolerance
Molecular mechanism of IL-10 gene regulation in lymphocytes and dendritic cells
Elucidation of the signaling pathways for IL-10 expression induced by commensal bacteria and probiotics.
Elucidation of the mechanism of probiotics-induced immune modulation
Characterization of regulatory DCs and regulatory T cells (iTreg) cells induced by probiotics
Development of antigen-specific immunotherapy for autoimmune disorders (Myasthenia gravis and rheumatoid arthritis)
Selected Publications
1. Kwon HK, Kim GC, Kim Y, Hwang W, Jash A, Sahoo A Nam JH, and Im SH. Amelioration of experimental autoimmune encephalomyelitis by probiotics mixture is mediated by a shift in T helper cell immune response. Clinical Immunology. 2013;146(3):217-227
2. Chae CS, Kwon HK, Hwang JS, Im SH. Prophylactic effect of probiotics on the development of experimental autoimmune myasthenia gravis. PLoS One. 2012;7(12):e52119
3. Lee IH, Kwon HK, An S, Kim D, Kim S, Yu MK, Lee JH, Lee TS, Im SH, Jon S. Imageable Antigen-Presenting Gold Nanoparticle Vaccines for Effective Cancer Immunotherapy In Vivo. Angew Chem Int Ed Engl. 2012;51(35):8800-5
4. Jash A, Sahoo A, Kim GC, Chae CS, Hwang JS, Kim JE, ImSH. NFAT induced permissive chromatin modification facilitates NF-κB mediated interleukin-9 (IL-9) transactivation. J Biol Chem. 2012;287(19):15445-57
5. Jash A, Yun KS, Sahoo A, So JS, Im SH. Looping mediated interaction between the promoter and 3′ UTR regulates type II collagen expression in chondrocytes. PLoS One. 2012;7(7):e40828.
6. Lee CG, Kwon HK, Sahoo A, Won H, So JS, Hwang JS, Chae CS, Kim GC, So HS, Hwang ES, Grenningloh R, Ho IC and ImSH. Interaction of Ets-1 with HDAC1 represses IL-10 expression in T helper 1 cells. J Immunol. 2012;188(5):2244-253
7. Son JS, Chae CS, Hwang JS, Park ZY, Im SH. Enhanced chromatin accessibility and recruitment of JUNB mediate the sustained IL-4 expression in NFAT1 deficient T helper 2 cells. PLoS One. 2011. 6(7): e22042
8. Lee IH, An S, Yu MK, Kwon HK, Im SH, Jon S. Targeted chemoimmunotherapy using drug-loaded aptamer-dendrimer bioconjugates. J Control Release. 2011; 155(3):435-41
9. Sahoo A, Lee CG, Jash A, Son JS, Kim G, Kwon HK, So JS, Im SH. Stat6 and c-Jun Mediate Th2 Cell-Specific IL-24 Gene Expression. J Immunol. 2011;186(7):4098-109
10. So JS, Song MK, Kwon HK a, Lee CG, Chae CS, Sahoo A, Jash A, Lee SH, Park ZY and Im SH. Lactobacillus casei enhances type II collagen/glucosamine-mediated suppression of inflammatory responses in experimental osteoarthritis. Life Sci. 2011;88(7-8):358-66
11. Kwon HK, Lee CG, Jae-Seon Soa, Chae CS, Hwang JS, Sahoo A, Nam JH, Rhee JH, Hwang KC, and Im SH Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders; Proc Natl Acad Sci U S A. 2010;107(5):2159-64. Commented by J Allergy Clin Immunol . May 2010. Page 953
12. Sahoo A and Im SH Interleukin and Interleukin Receptor Diversity: Role of Alternative Splicing. Int Rev Immunol. 2010;29(1):77-109
13. Lee CG, Won H, Maeng KE, Kwon HK, So JS, Sahoo A, Lee SH, Park ZY, ImSH. IRF4 regulates IL-10 gene expression in CD4+ T cells through differential nuclear translocation. Cell Immunol 2011;268: 97-104
14. Yun KS, So JS, Jash A and Im SH Lef1 regulates transcription through gene looping. J Immunol 2009 Oct 15;183(8):5129-37
15. CG Lee, KH Kang, JS So, HK Kwon, JS Son, MK Song, A Sahoo, HJ Yi, KC Hwang, T Matsuyama, K Yui, SH Im. A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells. Mol Immunol. 2009 Feb;46(4):613-21
16. Kwon HK, Jeon WK, Hwang JS, Lee CG, So JS, Park JA, Ko BS, Im SH. Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8(+) T cells. Cancer Lett. 2009; 278(2): 174-182
17. Lee CG, Kang KH, So JS, Kwon HK, JS Son JS, Song MK, Sahoo A, HJ HJ, KC Hwang, Matsuyama T, Yui K, Im SH. A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells. Mol Immunol. 2009;46(4):613-21
18. Sahoo A, Jung YM, Kwon HK, Yi HJi, Lee S, Chang S, Park ZY, Hwang KC, Im SH. A novel splicing variant of mouse IL-24 antagonizes IL-24-induced apoptosis. J Biol Chem. 2008. 43: 28860-28872.
19. Yi HJ, CS Chae, JS So, ST Tzartos, MC Souroujon, S Fuchs, SH Im. Suppression of Experimental Myasthenia Gravis by a B-cell Epitope-Free Recombinant Acetylcholine Receptor. Mol Immunol. 2008.09.15. 46(1):192-201
20. So JS, CG Lee, HK Kwon ,HJ Yi, CS Chae, JA Park, KC Hwang, SH Im. Lactobacillus casei potentiate induction of oral tolerance in experimental arthritis. Mol Immunol. 2008.09.18. 46(1):172-180
21. So JS, HK Kwon, CG Lee, HJ Yi, JA Park, SY Lim, KC Hwang, YH Jeon, SH Im. Lactobacillus casei suppresses experimental arthritis by down-regulating T helper 1 effector functions. Mol Immunol. 2008.02.19. 45(9):2690-2699
Education
2005 Ph.D, Cell Biology, Albert Einstein College of Medicine, NY
1998 Post M.Sc. Diploma, Center for Biotechnology, Jawaharlal Nehru University, New Delhi, India
1997 M.Sc. Department of Biochemistry, University of Calcutta, India
1995 B.Sc. Department of Chemistry, University of Calcutta, India
Research Experience
2009-2013: Research Fellow in the laboratory of Dr. Alexander Rudensky, Memorial Slogan-Kettering Cancer Center
2006-2008: Senior Fellow in the laboratory of Dr. Alexander Rudensky, University of Washington, Seattle
1999-2005: PhD student in Cell Biology Department in the laboratory of Dr. Jonathan R. Warner, Albert Einstein College of Medicine, Bronx, NY
Honors
2013 Wellcome Trust/ DBT India Alliance Intermediate fellowship
2011 Best Poster Presentation Award-- Immunology and Microbial Pathogenesis Graduate Program Retreat, Weill Cornell Graduate School of Medical Sciences
2007- 2010 Arthritis Foundation Postdoctoral fellowship
2009 Selected to attend RIKEN Research Center for allergy and Immunology (RCAI) summer program 2009, Yokohama, Japan
1997-1998 Post-M.Sc. Fellowship from the Center for Biotechnology, Jawaharlal Nehru University, New Delhi, India
1997 Shanti Bhakta Memorial Award for best paper presentation, Dept. of Biochemistry, University of Calcutta
Education and Training
1990 - 1996 B.S., Department of Biological Sciences, College of Natural Sciences,
Chonnam National University, Gkwangju, Korea
1998 M.S., Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Gyungbuk, Korea
2002 Ph.D., Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Gyungbuk, Korea
Professional Experiences
2002 - 2003 Postdoctoral fellow, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Korea
2003 - 2006 Postdoctoral fellow, Department of Immunology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA
2006 - 2010 Research Officer, Immunology Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
2010 - Senior Research Officer, Immunology Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
2010 - Visiting Assistant Professor, WCU Program, Division of Integrative Biosciences and Biotechnology, POSTECH, Pohang, Gyungbuk, Korea
Funding
Australian National Health and Medical Research Council (NHMRC) Project Grant; funded from 2011 till 2013 as a chief investigator
Research Assistant in Immune Regulation and Tolerance Lab.(Prof. Sin-Hyeog Im)
Research Assistant in Immune Regulation and Tolerance Lab.(Prof. Sin-Hyeog Im)